Paramedics were called to the M54 between Junction 2 and Junction 3 eastbound just after 11pm yesterday.
An ambulance, a paramedic officer, a MERIT trauma doctor and two senior paramedic officers were sent to the scene.
Claire Brown, spokeswoman for West Midlands Ambulance Service, said: "When ambulance staff arrived they found a motorcyclist, a man, in cardiac arrest.
"The team worked quickly to administer advanced life support on scene but sadly nothing could be done to save the man and he was confirmed dead a short time later.
"The car driver was assessed but didn’t require hospital treatment.”
Police and Highways England were also sent to the scene on the M54, which was closed while the crash was dealt with.